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Guideline Matrix - Part I

Zebrafish Preclinical Resource

Study TypeAnimal ModelOECD Guideline NameOECD TG No.Mode of ExposureStudy DurationSuitable Product Types
Acute ToxicityAdult Zebrafish (Danio rerio)Fish Acute Toxicity TestTG 203Aqueous Exposure96 HoursChemicals, Herbal Extracts, Nutraceuticals, Pharmaceuticals, Agrochemicals, Cosmetic Ingredients, Nano materials
Acute Embryo ToxicityZebrafish Embryos (0–96 hpf)Fish Embryo Acute Toxicity (FET) TestTG 236Aqueous Exposure96 Hours Post-FertilizationChemicals, Herbal Extracts, Nutraceuticals, Pharmaceuticals, Agrochemicals, Cosmetic Ingredients, Nano materials
Early-Life Stage ToxicityZebrafish (Embryo to Juvenile)Fish Early-Life Stage Toxicity TestTG 210Continuous Aqueous Exposure30–60 Days*Chemicals, Herbal Products, Nutraceuticals, Pharmaceuticals, Agrochemicals
Growth ToxicityJuvenile ZebrafishFish Juvenile Growth TestTG 215Aqueous Exposure28 DaysNutraceuticals, Herbal Products, Feed Additives, Pharmaceuticals, Chemicals
Reproductive ToxicitySexually Mature Adult ZebrafishFish Short-Term Reproduction AssayTG 229Aqueous Exposure21 DaysChemicals, Pharmaceuticals, Herbal Products, Nutraceuticals, Agrochemicals
Endocrine/Reproductive ScreeningSexually Mature Adult Zebrafish21-Day Fish AssayTG 230Aqueous Exposure21 DaysChemicals, Pharmaceuticals, Herbal Products, Nutraceuticals, Agrochemicals
Sexual Development ToxicityZebrafish (Embryo to Sexual Differentiation Stage)Fish Sexual Development TestTG 234Continuous Aqueous Exposure60–90 Days*Chemicals, Pharmaceuticals, Herbal Products, Nutraceuticals, Agrochemicals
Bioaccumulation StudyJuvenile or Adult ZebrafishBioaccumulation in Fish: Aqueous and Dietary ExposureTG 305Water and/or Dietary ExposureSeveral Weeks to MonthsChemicals, Pharmaceuticals, Agrochemicals, Herbal Extracts, Nutraceutical Ingredients
Guideline Matrix - Part III

Rat and Mice Toxicity Studies

Study TypeAnimal ModelOECD Guideline NameOECD TG No.Mode of ExposureCommon Strain(s)Study DurationSuitable Product Types
Acute Oral ToxicityRat (preferred), MouseAcute Oral Toxicity – Fixed Dose ProcedureTG 420Oral GavageWistar Rat, Sprague-Dawley Rat, Swiss Albino Mouse14 Days ObservationPharmaceuticals, Nutraceuticals, Herbal Products, Chemicals, Agrochemicals
Acute Oral ToxicityRat (preferred), MouseAcute Toxic Class MethodTG 423Oral GavageWistar Rat, Sprague-Dawley Rat, Swiss Albino Mouse14 Days ObservationPharmaceuticals, Nutraceuticals, Herbal Products, Chemicals, Agrochemicals
Acute Oral ToxicityRat (preferred), MouseAcute Oral Toxicity – Up-and-Down ProcedureTG 425Oral GavageWistar Rat, Sprague-Dawley Rat, Swiss Albino Mouse14 Days ObservationPharmaceuticals, Nutraceuticals, Herbal Products, Chemicals, Agrochemicals
Acute Dermal ToxicityRatAcute Dermal ToxicityTG 402Dermal ApplicationWistar Rat, Sprague-Dawley Rat14 Days ObservationCosmetics, Topical Products, Chemicals, Agrochemicals
Acute Inhalation ToxicityRatAcute Inhalation ToxicityTG 403InhalationWistar Rat, Sprague-Dawley Rat14 Days ObservationAerosols, Industrial Chemicals, Agrochemicals, Nanomaterials
Skin SensitisationMouseLocal Lymph Node Assay (LLNA)TG 429Dermal ApplicationCBA/J Mouse, BALB/c Mouse6 DaysCosmetics, Chemicals, Personal Care Products
Sub-acute ToxicityRatRepeated Dose 28-Day Oral Toxicity Study in RodentsTG 407Oral Gavage, Feed, Drinking WaterWistar Rat, Sprague-Dawley Rat28 DaysPharmaceuticals, Nutraceuticals, Herbal Products, Chemicals
Sub chronic ToxicityRatRepeated Dose 90-Day Oral Toxicity Study in RodentsTG 408Oral Gavage, Feed, Drinking WaterWistar Rat, Sprague-Dawley Rat90 DaysPharmaceuticals, Nutraceuticals, Herbal Products, Chemicals
Prenatal Developmental ToxicityPregnant Rat / MousePrenatal Developmental Toxicity StudyTG 414Oral (typically gavage)Wistar Rat, Sprague-Dawley Rat, CD-1 MouseGestation PeriodPharmaceuticals, Herbal Products, Nutraceuticals, Chemicals
Reproductive Toxicity ScreeningRatReproduction/Developmental Toxicity Screening TestTG 421Oral GavageWistar Rat, Sprague-Dawley Rat~6–8 WeeksPharmaceuticals, Nutraceuticals, Herbal Products, Chemicals
Combined Repeated Dose & Reproductive ToxicityRatCombined Repeated Dose Toxicity Study with Reproduction/Developmental Toxicity Screening TestTG 422Oral GavageWistar Rat, Sprague-Dawley Rat~6–8 WeeksPharmaceuticals, Nutraceuticals, Herbal Products, Chemicals
Neurotoxicity StudyRatNeurotoxicity Study in RodentsTG 424Usually Oral GavageWistar Rat, Sprague-Dawley RatProtocol DependentPharmaceuticals, Agrochemicals, Industrial Chemicals
Chronic ToxicityRatChronic Toxicity StudiesTG 452Oral, Dermal, or InhalationWistar Rat, Sprague-Dawley Rat≥12 MonthsPharmaceuticals, Chemicals, Agrochemicals
CarcinogenicityRat / MouseCarcinogenicity StudiesTG 451Oral, Dermal, or InhalationSprague-Dawley Rat, Wistar Rat, CD-1 Mouse, Swiss Albino Mouse18–24 MonthsPharmaceuticals, Chemicals, Agrochemicals
Chronic Toxicity & CarcinogenicityRatCombined Chronic Toxicity/Carcinogenicity StudiesTG 453Oral, Dermal, or InhalationWistar Rat, Sprague-Dawley RatUp to 24 MonthsPharmaceuticals, Chemicals, Agrochemicals
Extended One-Generation Reproductive ToxicityRatExtended One-Generation Reproductive Toxicity StudyTG 443Oral AdministrationWistar Rat, Sprague-Dawley RatSeveral MonthsPharmaceuticals, Chemicals, Agrochemicals, Nutraceuticals
Guidelines Directory
oecd-203 fish acute toxicity-testoecd-210 fish early life stage toxicity-testoecd-229 fish short term reproduction assayoecd-230 21 day fish assay a screening test for estrogenic and androgenic activity and aromatase inhibitionoecd-234 fish sexual development testoecd-236 fish embryo acute toxicity fet-testoecd-305 bioaccumulation in fish aqueous and dietary exposureoecd-215 fish juvenile growth testoecd-402-acute-dermal-toxicityoecd-403 acute inhalation toxicityoecd-407 repeated dose 28 day oral toxicity study in rodentsoecd-408 repeated dose 90 day oral toxicity study in rodentsoecd-414 prenatal developmental toxicity studyoecd-420 acute oral toxicity fixed dose procedureoecd-421 reproduction developmental toxicity screening testoecd-422 combined repeated dose toxicity study with the reproduction developmental toxicity screening testoecd-423 acute oral toxicity acute toxic class-methodoecd-424 neurotoxicity study in rodentsoecd-425 acute oral toxicity up and down procedureoecd-429 skin sensitisation local lymph node assayoecd-443 extended one generation reproductive toxicity studyoecd-451 carcinogenicity studiesoecd-452 chronic toxicity studiesoecd-453 combined chronic toxicity carcinogenicity studiesoecd-203 fish acute toxicity-testoecd-210 fish early life stage toxicity-testoecd-229 fish short term reproduction assayoecd-230 21 day fish assay a screening test for estrogenic and androgenic activity and aromatase inhibitionoecd-234 fish sexual development testoecd-236 fish embryo acute toxicity fet-testoecd-305 bioaccumulation in fish aqueous and dietary exposureoecd-215 fish juvenile growth testoecd-402-acute-dermal-toxicityoecd-403 acute inhalation toxicityoecd-407 repeated dose 28 day oral toxicity study in rodentsoecd-408 repeated dose 90 day oral toxicity study in rodentsoecd-414 prenatal developmental toxicity studyoecd-420 acute oral toxicity fixed dose procedureoecd-421 reproduction developmental toxicity screening testoecd-422 combined repeated dose toxicity study with the reproduction developmental toxicity screening testoecd-423 acute oral toxicity acute toxic class-methodoecd-424 neurotoxicity study in rodentsoecd-425 acute oral toxicity up and down procedureoecd-429 skin sensitisation local lymph node assayoecd-443 extended one generation reproductive toxicity studyoecd-451 carcinogenicity studiesoecd-452 chronic toxicity studiesoecd-453 combined chronic toxicity carcinogenicity studiesoecd-203 fish acute toxicity-testoecd-210 fish early life stage toxicity-testoecd-229 fish short term reproduction assayoecd-230 21 day fish assay a screening test for estrogenic and androgenic activity and aromatase inhibitionoecd-234 fish sexual development testoecd-236 fish embryo acute toxicity fet-testoecd-305 bioaccumulation in fish aqueous and dietary exposureoecd-215 fish juvenile growth testoecd-402-acute-dermal-toxicityoecd-403 acute inhalation toxicityoecd-407 repeated dose 28 day oral toxicity study in rodentsoecd-408 repeated dose 90 day oral toxicity study in rodentsoecd-414 prenatal developmental toxicity studyoecd-420 acute oral toxicity fixed dose procedureoecd-421 reproduction developmental toxicity screening testoecd-422 combined repeated dose toxicity study with the reproduction developmental toxicity screening testoecd-423 acute oral toxicity acute toxic class-methodoecd-424 neurotoxicity study in rodentsoecd-425 acute oral toxicity up and down procedureoecd-429 skin sensitisation local lymph node assayoecd-443 extended one generation reproductive toxicity studyoecd-451 carcinogenicity studiesoecd-452 chronic toxicity studiesoecd-453 combined chronic toxicity carcinogenicity studies
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